Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Helsinn Therapeutics (U.S.), Inc
Age
18–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Able to freely give written informed consent to participate in the study and have signed the Informed Consent Form
Males or females, 18 to 85 years of age inclusive at the time of study screening
American Society of Anesthesiologists (ASA) Class I-III
Have undergone a scheduled small and/or large open partial bowel resection based on a documented incision size greater than or equal to (≥) 10 cm with primary anastomosis
Females must not be pregnant as confirmed by a serum pregnancy test at screening and by a urine pregnancy test on the day of surgery
Body weight must be between 40-150 kilograms (kg)
You may not be if
Any procedure which requires a diverting stoma
Primary anastomosis not performed at the time of surgery
Epidural or intrathecal anesthesia
Significant liver disease (ALT and/or total bilirubin \> 2-fold upper limits of normal) or kidney disease (serum creatinine \> 2.5 mg/dL) at screening
History of irritable bowel syndrome
Patients with a history of Crohn's disease or ulcerative colitis (UC) who have had multiple GI-related surgeries (Note: surgery naïve Crohn's or UC patients may be included)
History of colonic volvulus
History of gastroesophageal surgery, gastrectomy, gastric bypass, total colectomy, short bowel syndrome, or multiple complex abdominal surgeries performed by an open procedure (uncomplicated cesarean section and appendectomy would not be considered complex)
Patients who have received prior abdominal radiation and/or pelvic radiation
