Study of PTPN22 C1858T Polymorphism in Children and Adolescents of Greek Origin With T1DM

Inclusion Criteria

• •For the patients
• •Diagnosis of T1DM according to American Diabetes Association (ADA) Criteria as well as according to International Society for Pediatric and Adolescent Diabetes (ISPAD) Guidelines
• •Unrelated male and female subjects
• •1-20 years of age
• •Come from Greece (At least 3 grandparents are Greek)
• •At least one year post onset of T1DM
• •Sign written informed consent
• •For the controls
• •Unrelated nondiabetic male and female subjects with no family history of T1DM
• •Equal to or greater than 18 years of age
• •Come from Greece (At least 3 grandparents are Greek)
• •Be screened by a questionnaire to ensure the absence of any diagnostic evidence of autoimmune diseases or family history (first- or second-degree relatives) of T1DM
• •Sign written informed consent