Finding studies
Finding studies
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Lead
Dana-Farber Cancer Institute
With
Primary Objective * To determine the efficacy of single-agent hydroxychloroquine in patients with metastatic pancreatic cancer previously treated with one or two prior chemotherapy regimens as measured by progression-free survival at two months Secondary Objectives * To assess tumor response rate, biochemical response rate (i.e. decrease in serum CA19-9 by \> 30%), and overall survival Translational/Exploratory Objectives * To investigate predictors of response to anti-autophagy therapy with hydroxychloroquine * To explore the kinetics of in vivo autophagy inhibition using peripheral blood WBCs to monitor autophagic activity among patients receiving hydroxychloroquine
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted