Combination of AUY922 With Trastuzumab in HER2+ Advanced Breast Cancer Patients Previously Treated With Trastuzumab

Exclusion Criteria

• •Patients with known CNS metastasis which are: symptomatic or require treatment for symptom control and/or growing
• •Prior treatment with any HSP90 or HDAC inhibitor
• •Impaired cardiac function
• •Acute or chronic liver or renal disease
• •Patients who are currently receiving treatment with any medication which has a relative risk of prolonging the QTc interval or inducing Torsades de Pointes and cannot be switched or discontinued to an alternative drug prior to commencing AUY922
• •Patients with a history of another primary malignancy that is currently clinically significant or currently requires active intervention
• •Patients who do not have either an archival tumor sample available or are unwilling to have a fresh tumor sample collected at baseline.