Saracatinib in Treating Patients With Prostate Cancer

PRIMARY OBJECTIVES: I. Determine if AZD0530 (saracatinib) increases time to radiographic progression in men with CRPC compared to placebo. SECONDARY OBJECTIVES: I. Describe the adverse events related to AZD0530 in this population. II. Explore the role of FYN and other SRC kinase expression as a predictor of response to AZD0530. OUTLINE: This is a multicenter study. LEAD-IN PHASE: Patients receive oral saracatinib once daily during for 8 weeks. Patients who achieve disease regression or a PSA decrease of \> 50% continue to receive open-label saracatinib. Patients who do not show radiographic evidence of new metastases on bone scan and CT, disease regression, or a \> 50% decrease in PSA continue on to the randomized phase. RANDOMIZED PHASE: Patients are randomized to 1 of 2 treatment arms. ARM I: Patients receive oral saracatinib once daily on days 1-28. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. ARM II: Patients receive oral placebo once daily on days 1-28. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. Upon progression, patients may crossover to arm I. Tissue samples may be collected for correlative studies. After completion of study treatment, patients are followed up for 12 months.