A Study of LY2216684 in Major Depressive Disorder in Patients Taking Selective Serotonin Reuptake Inhibitors

Exclusion Criteria

• •Are currently enrolled in, or discontinued within the last 30 days from, a clinical trial involving an investigational drug or device or off-label use of a drug or device other than the study drug used in this study, or are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study.
• •Have known allergies to any compound related to LY2216684.
• •Are persons who have previously completed or withdrawn from this study or any other study investigating LY2216684.
• •Have a clinically significant abnormality in the 12-lead electrocardiogram (ECG) that, in the opinion of the investigator, increases the risks associated with participating in the study.
• •Have a significant history of or presence of cardiovascular (including dysrhythmias), respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, or neurological disorders, or any condition capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the study medication; or of interfering with the interpretation of data.
• •Have unequal BP (\> 20 millimeter of mercury \[mm Hg\]) in the left arm versus right arm (as measured with a BP cuff) or have absent or unequal radial pulses in either arm.
• •Have a history of seizure disorders.
• •Regularly use known drugs of abuse and/or show positive findings on urinary drug screening.
• •Show evidence of human immunodeficiency virus (HIV) and/or positive human HIV antibodies.
• •Show evidence of hepatitis C and/or positive hepatitis C antibody.
• •Show evidence of hepatitis B and/or positive hepatitis B surface antigen.
• •Are women with a positive pregnancy test or women who are lactating.
• •Use of over-the-counter or prescription medication (other than stable doses of SSRI as noted above) with a narrow therapeutic index (including, but not limited to warfarin or clopidogrel) or those that are known to have an effect on heart rate (e.g., beta-blockers) within 14 days prior to dosing.
• •Use of any drugs or substances that are known to be a strong inducer or inhibitor of cytochrome P450 2D6 (CYP2D6) or cytochrome P450 3A4 (CYP3A4) within 30 days prior to check-in (study entry) and during the conduct of the study.
• •Have donated blood of more than 500 milliliter (mL) within 4 weeks prior to screening.
• •Have an average weekly alcohol intake that exceeds 14 units per week, or are unwilling to stop alcohol consumption 48 hours prior to check-in (study entry)until the completion of the study (1 unit = 12 ounces \[oz\] or 360 mL of beer; 5 oz or 150 mL of wine; 1.5 oz or 45 mL of distilled spirits).
• •Consume 5 or more cups of coffee (or other beverages of comparable caffeine content) per day, on a habitual basis, or any patients unwilling to adhere to study caffeine restrictions.
• •Patients must adhere to the smoking restrictions of the Clinical Research Unit (CRU) while a resident of the CRU.
• •Have consumed grapefruit or grapefruit-containing products 7 days prior to enrollment or are unwilling to avoid during the study.
• •Have a documented or suspected history of glaucoma.
• •Patients determined to be unsuitable by the investigator for any reason.