Effect of Weight Loss on Breast Density Using Digital Mammography and MRI in Women Who Are At Increased Risk For Breast Cancer

Exclusion Criteria

• •Women with a history of breast cancer
• •Women currently taking exogenous hormone replacement therapy
• •Women currently taking a SERM
• •Women currently taking an aromatase inhibitor
• •Pregnant or lactating women
• •Women who have been pregnant or lactating in the past 2 years
• •Women who have metallic or other surgical implants
• •All subjects will have a determination of their estimated glomerular filtration rate (eGFR) within 24 hours of undergoing any study where gadolinium based contrast agents will be administered
• •Subjects should not have a known history of recent onset acute renal dysfunction
• •Subjects with a history of stable chronic renal dysfunction may participate in studies using GBCA based on their eGFR, as outlined below
• •Subjects should not have severe liver dysfunction, particularly when associated with kidney disease
• •Subjects should receive GBCAs in the perioperative period (i.e. within 4 weeks) after renal or liver transplantation