BRCA Mutations in Latinas

BACKGROUND: * Mutations in the BRCA1 and BRCA2 genes predispose to breast and ovarian cancer, and are increasingly recognized in prostate and pancreatic cancers. * Basal/ Triple negative breast cancer is associated with BRCA mutations in some ethnicities.However the link between BRCA gene mutations and Basil/ triple negative disease in Hispanic/ Latino women is not known. * Common recurrent mutations in BRCA1 and BRCA2 exist in Hispanic/ Latino communities. * New therapies such as PARP inhibitors may be particularly effective in BRCA mutation carriers. * Therefore a unique opportunity exists to identify women in this underserved minority that may be eligible for and benefit from new targeted therapies. OBJECTIVES: \- The primary objective is to collect saliva samples and histology data from up to 2000 Hispanic/ Latino subjects with breast cancer as a source of DNA, and to analyze the BRCA1 and BRCA2 genes.. ELIGIBILITY: \- All Hispanics females, over the age of 18, with breast cancer will be eligible. DESIGN: \- Natural history study of 2000 Hispanic/Latino women with breast cancer, 1000 with triple negative disease, 1000 without. * Obtain clinical pathology reports and relevant history data on all subjects. * Analyze recurrent BRCA1 and BRCA2 mutations