Human Cytochrome P450 4F Enzymes and Drug Interactions

Exclusion Criteria

• •History of intolerance, allergy, or hypersensitivity to study drugs warfarin and lovastatin or any substances contained in the medication
• •History of clotting disorders, stroke, hypertension, anemia, renal insufficiency, hepatic dysfunction, platelet dysfunction, gastrointestinal bleeding, or any recent bleeding episode or trauma within 6 months
• •History of significant medical conditions that the study physician believes would increase risk (e.g., additional bleeding disorders)
• •Genotype non-homozygous for CYP2C9\*1 or genotype VKORC1-1639AA
• •History of significant alcohol abuse and/or illicit drug use
• •Tobacco use within the month preceding the study
• •Woman who is pregnant or breastfeeding
• •Women who are unable to maintain adequate birth control during the study
• •Post-menopausal women on estrogen replacement
• •Chronic statin or warfarin use
• •Taking concomitant medications, both prescription and non-prescription (including herbal products, over-the-counter medications, and multivitamins), known to alter lovastatin, warfarin, or vitamin K blood levels (women stabilized on hormonal methods of birth control will be allowed to participate, and subjects stabilized on antidepressant medications will be allowed to participate)
• •Recent use of antibacterial antibiotics
• •Recent blood donation or participation in other clinical studies within past 8 weeks