An Open-Label, Dose-Escalation Study of AZD2461

Inclusion Criteria

• •Patients with confirmed diagnosis of solid tumor malignancy that is not responsive to standard therapies or for which there is no effective therapy.
• •Eastern Cooperative Group (ECOG) Performance Status score of 0 or 1
• •Patients must be 18 years of age
• •Using adequate contraceptive measures, be surgically sterile or post-menopausal
• •Patients entering this study must be willing to provide tissue from a previous tumor biopsy (if available) for correlative testing. If tissue is not available, a patient will still be eligible for enrollment into the study..