Microvascular Flow Assessment Repeatability Study: The MARS Study

Exclusion Criteria

• •Subjects must not have been diagnosed with:
• •1. Coronary artery disease
• •2. Congestive heart failure
• •3. Congenital heart disease (Right-to-left, bi-directional, or transient right-to-left cardiac shunts)
• •4. Hypersensitivity to perflutren
• •5. Renal disease
• •6. Chronic obstructive pulmonary disease or Asthma
• •7. Primary or secondary pulmonary hypertension
• •8. Obstructive sleep apnea
• •9. Thyroid disease
• •10. Vasculitis
• •11. Peripheral arterial disease.
• •12. Cancer
• •13. Any type of immunosuppression
• •14. Any active infection (systemic or of the underlying skin or subcutaneous tissue).
• •15. Taking any prescribed medication for hypertension, dyslipidemia or diabetes.
• •16. Current or past smoking in the last 12 months.
• •17. Positive urine pregnancy test
• •18. Creatinine (Cr) above 1.4 mg/dl on screening evaluation
• •19. Hemoglobin (Hb) less than 10 mg/dl on screening evaluation
• •20. Aspartate Transaminase (AST) or Alanine Transaminase (ALT) two fold above upper limit of normal on screening evaluation