Safety and Efficacy of S-707106 in Subjects With Type 2 Diabetes Mellitus and Inadequate Glycemic Control With Metformin Therapy

Exclusion Criteria

• •Type 1 diabetes mellitus or gestational diabetes mellitus within last 6 months
• •Use of any medication for glycemic control other than metformin during the past 3 months or thiazolidinediones within the past year
• •Congestive heart failure as defined by New York Heart Association class III or IV
• •Fasting glucose \>270 mg/dL
• •Creatinine clearance is \<60 mL/minute
• •History of myocardial infarction within the past 3 months, history of clinically significant cardiac arrhythmia, clinically significant hypotension or hypertension, or clinically significant abnormal electrocardiogram as determined by the investigator