Nicotinic Modulation of the Default Network of Resting Brain Function

Exclusion Criteria

• •1. Presence of metal objects in the body, implanted electronic devices, or any other counter indication for MRI.
• •2. Claustrophobia.
• •3. Major psychiatric disorders including mood, anxiety or psychotic disorders.
• •4. Cardiovascular or cerebrovascular disease, such as history of myocardial infarction, heart failure, angina, stroke, severe arrhythmias, or EKG abnormalities as specified under Screening methods .
• •5. Kidney or liver disease.
• •6. Hypertension (resting systolic BP above 140 or diastolic above 85 mm Hg).
• •7. Hypotension (resting systolic BP below 95 or diastolic below 60).
• •8. Use of any prescription or over-the-counter drug other than supplements and birth control.
• •9. History of or current neurological illnesses, such as stroke, seizures, dementia or organic brain syndrome.
• •10. Learning disability, attention deficit disorder, or any other condition that impedes memory and attention.
• •11. Glaucoma, organic pyloric stenosis, uremia or renal insufficiency (see Mecamylamine-related risks).
• •12. Prostatic hypertrophy, bladder neck obstruction or urethral stricture (see Mecamylamine-related risks).
• •13. Left-handed or ambidextrous.
• •14. Pregnant as determined by urine test, or breast-feeding.
• •15. History or current diagnosis of drug or alcohol abuse or dependence.
• •16. IQ \< 85 as estimated by the WASI vocabulary subtest.
• •17. Strong disposition to get car sick.