Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)

Exclusion Criteria

• •Symptoms of lower gastrointestinal tract disease warranting colonoscopic evaluation, including:
• •* More than one episode of rectal bleeding within the past 6 months
• •* Documented iron deficiency anemia
• •* Significant documented unintentional weight loss (\>10% of baseline weight) over 6 months
• •Family history of CRC in a first degree relative at any age
• •Prior history of colonic disease including:
• •* Inflammatory bowel disease (e.g. ulcerative colitis or Crohn's disease)
• •* One or more colorectal neoplastic polyps (i.e. adenomas)
• •* Colorectal cancer
• •Prior history of colonic resection
• •Prior colonic examination, including:
• •* Colonoscopy within the past 9.5 years
• •* Sigmoidoscopy within the past 5 years
• •* Barium enema within the past 5 years
• •* CT colonography within the past 5 years
• •gFOBT or FIT in the past 10 months
• •Stool DNA test within the past 3 years
• •Pregnancy
• •Prisoner
• •Significant comorbidity that would preclude benefit from screening or pose significant risk for the performance of colonoscopy (e.g. severe lung disease, end-stage renal disease, end-stage liver disease, severe heart failure, recent diagnosis of cancer (with the exception of non-melanoma skin cancer))
• •Likely inability to track the individual over time (e.g. no permanent address at the time of screening for study entry)