Current psychiatric diagnosis other than schizophrenia

Alcohol or substance dependence within 3 months or abuse within 1 month (except for nicotine)

Electro-convulsive therapy (ECT) within the prior 6 months

Previous treatment with RO4917838 or another GLYT inhibitor

Current treatment with olanzapine, or previous treatment with intolerability or lack of response

Treatment with long-acting injectable antipsychotic within 2 dosing intervals

Treatment with \> 2 antipsychotics within 3 months

History of neuroleptic malignant syndrome

Have treatment-resistant schizophrenia as judged by treating physician or have failed two trials according to criteria in protocol

A Study of RO4917838 (Bitopertin) in Patients With Acute Exacerbation of Schizophrenia