1. Currently therapeutically anticoagulated for known thrombotic diagnosis (myocardial infarction, venous thromboembolism) known molecular hypercoagulable state (Factor V Leiden, lupus anticoagulant, antiphospholipid antibody syndrome); or use of cardiopulmonary support machines (left-ventricular assist device, intra-aortic balloon pump, veno-venous ultrafiltration, or extracorporeal membrane oxygenation.

2. History of gastrointestinal or cerebral hemorrhage within past 3 months;

3. Active bleeding;

4. Known allergy or sensitivity to heparin;

5. History of heparin-induced thrombocytopenia

6. Organ transplantation recipient -

Safety of Heparin in Patients With Septic Shock

What this study is about