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UNKNOWNNANCT01231360

The Effect of Exercise Training on Skeletal Muscle Metabolism in Peripheral Artery Disease (PAD)

Specific Aim 1: To test the hypothesis that subjects with PAD and intermittent claudication have altered expression of genes that regulate skeletal muscle metabolism. Specific Aim 2: To test the hypo...

Lead sponsor: Brigham and Women's Hospital•1 U.S. locations•View source on ClinicalTrials.gov

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Contacts

Jessica Milian, BA

CONTACT

617-732-6320 jmilian@partners.org

Sponsors

Lead Sponsor

Brigham and Women's Hospital

Collaborators

American Heart Association
Joslin Diabetes Center

Age

40 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•claudication symptoms
•ABI ≤ 0.9 in the symptomatic leg

Exclusion Criteria

•diabetes
•impaired fasting glucose
•peripheral vascular intervention within the prior six months
•recent unstable angina
•myocardial infarction or stroke within the prior six months
•changes to their HMG-CoA reductase inhibitor (statin)within the past three months
•changes to pentoxifylline and/or cilostazol regimen within the past three months or anticipated to be necessary during the study
•are on Coumadin
•exercise limitations for reasons other than intermittent claudication (such as congestive heart failure, angina, chronic lung disease, or other disorders affecting the limb such as arthritis or neuropathy)
•rest pain or ulcers due to critical limb ischemia
•lower extremity amputation

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 22, 2013Terms

Trial snapshot

StatusUNKNOWN

PhaseNA

Enrollment75

Start dateOct 2010

Last updatedFeb 22, 2013

Condition

Locations shown

Brigham and Women's Hospital

Boston, Massachusetts

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 22, 2013Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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