Clareo Health | A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Relationship Between Intraoperative Intravenous Acetaminophen and Postoperative Opioid Avoidance for Ambulatory Surgical Procedures
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Relationship Between Intraoperative Intravenous Acetaminophen and Postoperative Opioid Avoidance for Ambulatory Surgical Procedures
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of California, San Diego
With
Cadence Pharmaceuticals
Primary Specific Aim: To determine if adding an intraoperative dose of intravenous acetaminphen to usual and customary analgesics during ambulatory surgery impacts the proportion of patients remaining opioid-free in the post-anesthesia recovery room.
Hypothesis: Adding an intraoperative dose of intravenous acetaminophen to usual and customary analgesics during ambulatory surgery increases the proportion of patients remaining opioid-free in the post-anesthesia recovery room.
Secondary Specific Aim: To determine if adding an intraoperative dose of intravenous acetaminophen to usual and customary analgesics during amublatory surgery impacts the required doses of additional perioperative analgesics.
Hypothesis: Adding an intraoperative dose of intravenous acetaminophen to usual and customary analgesics during ambulatory surgery decreases the required doses of additional analgesics in both the operating room and post-anesthesia recovery room.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Undergoing ambulatory surgery under general anesthesia
Expected postoperative pain to be mild-moderate
Age 18 years or older
Have an ASA physical status or 1, 2, or 3
You may not be if
Anticipated peripheral or neuraxial nerve block
Any physical, mental or medical conditions which may confound quantifying postoperative pain resulting from surgery
Current chronic opioid or tramadol use
History of alcohol or opioid abuse
Known allergy to the study medications
Pregnancy
Any health condition requiring greater than 100 micrograms of fentanyl during anesthesia induction
Treated with any acetaminophen-containing medication in the previous 8 hours
Treated with MAO inhibitors within 10 days prior to surgery
Inability to communicate with the investigators and hospital staff