Nicotine and Brain Imaging Research Study

Inclusion Criteria

• •Women ages 18-50 will be eligible for this study if they:
• •Meet DSM-IV criteria for nicotine dependence for at least the past 2 years;
• •Smoke 10-30 cigarettes per day for the past two years;
• •Have clear urine toxicology screen upon recruitment and a plasma cotinine level of \> 210 ng/ml;
• •Have an expired CO (carbon monoxide) level of \> 11ppm;
• •Have regular menstrual cycles 24 to 36 days in length;
• •Do not have an elevated follicular stimulating hormone (FSH) \>20 (\>20 is potentially indicative of menopause and would be an exclusion criterion);
• •Have no history of major depressive disorder, generalized anxiety disorder, and or panic disorder within the last three years according to the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-NP) (First et al., 1995); a history of major depressive disorder, generalized anxiety disorder, and or panic disorder greater than 3 years ago, but now resolved according to the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-NP) (First et al., 1995), is allowed;
• •Have no substance abuse disorders (this includes alcohol, prescription, and illicit substances) within the last three years other than nicotine dependence according to the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-NP) (First et al., 1995);
• •Subject has history of substance abuse disorders (this includes alcohol, prescription, and illicit substances) \>3 years ago but the period of abuse did not last more than 5 years according to the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-NP) (First et al., 1995);
• •No history of clinically interfering premenstrual mood changes;
• •Are able to give written informed consent;
• •Are fluent in written and spoken English.