Safety And Efficacy Of Oral PF-4136309 In Patients With Chronic Hepatitis C Infection And Abnormal Liver Enzymes

Exclusion Criteria

• •Decompensated or severe liver disease defined by one or more of the following criteria:
• •Prior liver biopsy showing cirrhosis.
• •International Normalized Ratio (INR) greater than or equal to 1.5.
• •Total bilirubin greater than or equal to 1.5X ULN, or \>2X ULN for unconjugated bilirubin.
• •Serum albumin below normal.
• •ALT or aspartate aminotransferase (AST) \>10 x ULN.
• •Evidence of portal hypertension including splenomegaly, ascites, encephalopathy, and/or esophageal varices.
• •Presence of human immunodeficiency virus (HIV).
• •Co-infection with hepatitis B virus (HBV).
• •Co-infection with Epstein Barr Virus (EBV) and/or Cytomegalovirus (CMV).