Patients are required to have at least 3 of 66 joints assessed as swollen
Patients are required to have at least 6 of 68 joints assessed as painful with pressure
You may not be if
Pregnant or breast-feeding patients. Patients who plan to bear children or breast-feed during the study and within 6 month after completion of study
Previous experience of tacrolimus (ointment excluded)
Renal impairment or serum creatinine \> 1.4 mg/dL
Liver function failure as follows: viral hepatitis, non-viral hepatitis, cirrhosis, SGOT/SGPT \> 2x upper limit normal
Patients with history of pancreatitis, glucose intolerance or complication or who indicates any of the following criteria:Blood glucose level \>110mg/dl before the meal and \>200mg/dl after the meal HbA1c \> 6.4%
