Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy

Inclusion Criteria

• •Histologically or cytologically confirmed diagnosis of cancer (including epithelial carcinoma, sarcoma, and melanoma) The diagnosis can be done at MSKCC or at participating institutions.
• •Sites of metastatic disease to be treated on protocol are limited to bone, spine, soft tissue, and lymph nodes only.
• •Patients with American Joint Committee on Cancer (6th edition, 2002) Stage IV cancer with distant metastases
• •Age 18 years or older
• •Life expectancy \>3 months
• •Maximum tumor dimension of ≤6 cm in lymph nodes, soft tissue, osseous metastases, or spinal metastases seen on imaging (computed tomography \[CT\], magnetic resonance imaging \[MRI\], or PET/CT) and considered amenable for RT.
• •If the lesion(s) to be treated are soft-tissue or lymph Nodes unidimensionally measurable disease is required. Bone \& spine lesions are eligible even if considered non-measurable.
• •Measurable disease is defined as:
• •≥ 10mm for soft-tissue lesions
• •≥ 15mm on the short axis of lymph nodes
• •KPS ≥ 80
• •Patients must have normal bone marrow function as defined below:(within 2 months of registration) Hemoglobin ≥9.0 g/dl Absolute neutrophil count (ANC) ≥1,500/μl Platelets ≥100,000/μl