Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Institut Cancerologie de l'Ouest
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age \> or = 18 years
Social Insurance
Performance Index \<2
Life expectancy\> 6 months
adenocarcinoma colorectal (histologically proven)
Metastases (inoperable or recurrent after surgery),
hepatic localization and / or lung (up to 3 if one organ metastasis or 3 in total if the two bodies are metastatic). The largest diameter of the metastasis will \< ou = 6cm for the liver, \< or = 6 cm for the lung. If multiple metastases, the sum of their maximum diameter is 6cm \< ou = the liver, \< ou = 6 cm for the lung.
Lesion (s) measurable (s) and evaluable (s)
CT less than 3 weeks
Patients must have received at least one prior chemotherapy regimen containing 5FU
• Patients may have received one or more lines of chemotherapy including irinotecan.
TP, TCA Normal (only for patients treated with a permanent implant)
Informed consent signed.
You may not be if
contraindication to the administration of irinotecan.
History of radiotherapy in the thoraco-abdominal-cons indicating further irradiation.
History of other invasive cancer treated in a period of less than 5 years (basal cell carcinoma and non-invasive cervical excepted)
Metastatic disease diffuse or more than three metastases in the liver and / or lung during the natural history of disease (excluding any patient is having a complete radiological response on several metastases although 1-3 residual after treatment ( s) medical (at)).
Location (s) tumor (s) = CTV to less than 12 mm laterally or less than 15 mm in the cranio-caudal, stomach, small intestine, esophagus, trachea, bronchi of right and left pulmonary arteries and right and left.
Pregnancy or breastfeeding.
\- Lack of means or refusal to use effective contraception for men or women of childbearing age.
Any other concomitant experimental treatment.
Any other concurrent anticancer therapy, immunotherapy or hormonal therapy.
Monitoring impossible because of psychological, sociological or because of geographical distance.
