Evaluation of the Effect of the InsuPatch Device on Insulin Pharmacokinetics in Clamp Studies

Exclusion Criteria

• •1. Pregnancy
• •2. Breast feeding women.
• •3. Alcohol addiction
• •4. Had CABG (Coronary Artery Bypass Graft), are Post MI (Myocardial Infarction) or had active Ischemic heart disease prior to the study date
• •5. Had CVA (cardiovascular accident) or TIA (transient ischemic accident) prior to the study
• •6. Suffer from uncontrolled Hypertension (blood pressure in mm HG \>160 systolic or \> 95 diastolic)
• •7. Low blood hemoglobin concentration \<9 g/dL for female and \<11g/dL for male.
• •8. Abnormal kidney and/ or liver function tests. (If any of the liver or kidney function test parameters are greater than 3 fold normal values.
• •9. Subjects with Hyperthyroidism or Hypothyroidism with TSH level outside the normal range, TSH\>5.5 mIU/L or TSH\<0.4 mIU/L
• •10. Psychological incompetence
• •11. Any other clinical condition or history, that seems to be relevant to the principle investigator to disqualify the participant.
• •12. Subjects with diminished skin integrity
• •13. Subjects with heat sensitivity
• •14. Subjects involved in or planed to participate in other studies
• •15. Subjects using other drugs therapies to control blood glucose level other than insulin.