Phase II Study of Intra-Operative Electron Irradiation and External Beam Irradiation After Lumpectomy in Patients With T1N0M0 and T2N0M0 Breast Cancer

You may be eligible if

• Eligibility:
• 1. Histologically proven primary invasive breast carcinoma.
• 2. Tumor pathologically determined \<= 5cm in diameter.
• 3. Single, discrete, well-defined primary tumor.
• 4. Any micro-calcifications must be focal. A specimen radiograph is required after lumpectomy to assure removal of all malignant appearing calcifications.
• 5. Pathologically negative surgical margins.
• 6. Axillary lymph node status can be determined by level I and II lymph node dissection or sentinel lymph node sampling.
• 7. ECOG performance status 0-2.
• Contraindications:
• 1. Multicentric disease and/or diffuse malignant appearing microcalcifications.
• 2. Evidence of metastatic breast cancer.
• 3. Axillary lymph node involvement.
• 4. Pre-existing collagen vascular disease except rheumatoid arthritis that does not require immunosuppressive therapy.
• 5. Prior irradiation to the ara of planned radiation field.
• 6. Pregnant or lactating women.