ProspectiveTrial of Proton Beam Combined With Anti-VEGF Therapy for Exudative Age-related Macular Degeneration (AMD)

Exclusion Criteria

• •Subjects who meet any of the following criteria will be excluded from this study:
• •* Prior enrollment in the study
• •* Pregnancy (positive pregnancy test) or lactation
• •* Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated
• •* Participation in another simultaneous medical investigation or trial
• •* Previous treatment with Photodynamic Therapy (PDT) or thermal laser in study eye
• •* Anti-VEGF therapy within 6 weeks
• •* Intravitreal or subtenon's Kenalog within 6 months
• •* Intraocular surgery within 3 months or expected in the next 6 months
• •* Current or planned participation in other experimental treatments for wet AMD
• •* Other concurrent retinopathy or optic neuropathy
• •* Other causes of CNVM, i.e. myopic degeneration or ocular histoplasmosis (POHS)
• •* Significant media opacity precluding adequate view of the fundus for exam, photography or OCT
• •* History of radiation therapy to the head or study eye
• •* Diabetes mellitus or hemoglobin A1c \> 6
• •* Head tremor or h/o claustrophobia precluding positioning for proton irradiation
• •* Inability to maintain steady fixation with either eye
• •* History of Malignancy treated within 5 years
• •* Allergy to Fluorescein dye