Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction

Inclusion Criteria

• •Patients must have histologically confirmed in-situ or invasive breast carcinoma.
• •Tis, T1, T2 invasive or non-invasive carcinoma of the breast; lesion less than 4 cm.
• •Unifocal, multifocal or multicentric breast cancers that can be removed by nipple sparing mastectomy with negative surgical margins.
• •No extensive intraductal component or patient with distant metastases.
• •Patients must be \> 18 years of age.
• •No concomitant or history of nipple discharge or skin involvement.
• •No prior history of malignancy (less than 5 years prior to study entry), except non-melanomatous skin cancer.
• •No prior history of radiation to the chest.
• •No collagenous disease (systemic lupus erythematosis, scleroderma, dermatomyositis)No previous non-hormonal therapy including radiation or chemotherapy for current breast cancer.
• •No patients with Paget's disease of the nipple.
• •No patients with co-existing medical conditions with life expectancy \< 2 years.
• •No pregnant or lactating women.
• •Eastern Cooperative Oncology Group (ECOG) 0 - 2.
• •Signed study-specific informed consent form prior to the study entry.