Methadone in Neuropathic Pain

Exclusion Criteria

• •Patients on a dose of opioid that exceeds 90 mg/24 hours in OME
• •Pregnant or lactating women (women of childbearing potential must have negative pregnancy test)
• •History of psychosis
• •History of (within the past 2 years) , or current, substance dependency disorder
• •Excluded medications are listed in Appendix 1.
• •Presence of clinically significant cardiac or pulmonary disorder on physical exam that would compromise participants' safety in the trial as judged by the study physician.
• •Presence of significant conduction delay, ischemia or arrhythmia on screening ECG
• •Presence of severe pain disorder other than the chronic neuropathic pain under study that would interfere with patient's ability to determine effect of study treatment on the chronic neuropathic pain
• •Abnormalities above 1.5 times upper range of normal on screening CBC, blood chemistry including BUN, Cr, LDH, AST, ALT
• •Patients with a history of allergy to any opioid.
• •Participation in another clinical trial in the 30 days prior to enrolment.