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Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT) | Clinical Trials | Clareo Health

COMPLETEDPHASE4

Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT)

Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima Media Thickness and Its Relation to Plaque Components of the Coronary Arteries in Patients With ST-Segment Elevation Acute Myocardial Infarction

NCT01203982•Odense University Hospital

View on ClinicalTrials.gov

Summary

The aim of this study was to measure the effect of moderate and intensive lipid-lowering treatment with rosuvastatin on the carotid intima-media thickness (CIMT) as a surrogate marker of cardiovascular risk.

Detailed Description

The aim of this study was to measure the effect of moderate (5mg) and intensive (40mg) lipid-lowering treatment with rosuvastatin on the carotid intima-media thickness as a surrogate marker of cardiovascular risk and to obtain whether CIMT correlated with the plaque components in coronary arteries evaluated with Intravascular Ultrasound Virtual Histology (IVUS-VH).

Eligibility

Age

18 - 81 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. STEMI,
•2. no prior treatment with statins and
•3. a non significant lesion in one of the two non-culprit coronary arteries. -

Exclusion Criteria

•1. age below 18 or above 81 years,
•2. unconscious patients,
•3. serum creatinine \> 176μmol/L,
•4. total-cholesterol \> 7.0 mmol/l,
•5. hypothyroidism ((TSH \> 1.5 x ULN (upper limit of normal)),
•6. current liver disease (ALAT \> 2 x ULN),
•7. unexplained creatine kinase \> 3 x ULN,
•8. alcohol or drug abuse within the last five years,
•9. prior myopathy or serious hypersensitivity reaction caused by statins,
•10. women with childbearing potential who were not using chemical or mechanical contraception,
+5 more criteria

Locations (1)

Department of Cardiology, Odense University Hospital

Odense, Fuenen, Denmark

Key Dates

Start Date

November 1, 2007

Completion Date

June 1, 2009

Last Updated

September 17, 2010

Enrollment

ACTUAL participants

Conditions

ST-segment Elevation Myocardial InfarctionSubclinical Carotid Atherosclerosis

Interventions

Rosuvastatin

DRUG

Rosuvastatin

DRUG

Short-Term Outcomes of Early Administration of Colchicine in Non-ST Segment Elevation Myocardial Infarction Patients Treated With Drug-Eluting Stents.

NCT07143136

Non ST-Segment Elevation Myocardial Infarction

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RECRUITINGNA

The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction

NCT06385834

ST-segment Elevation Myocardial Infarction (STEMI)

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TERMINATEDPHASE3

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 17, 2010Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT)

Inclusion Criteria

Exclusion Criteria

Short-Term Outcomes of Early Administration of Colchicine in Non-ST Segment Elevation Myocardial Infarction Patients Treated With Drug-Eluting Stents.

The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction

Effect of Low-dose Intracoronary Reteplase on Myocardial Infarct Size During Primary Percutaneous Coronary Intervention

Prognostic Implication of Angiography-Derived IMR in STEMI Patients

The Efficacy and Safety of Ketotifen in Primary PCI Patients With STEMI

Kitasato PCI Registry