A Rheumatoid Arthritis Study in Participants

Exclusion Criteria

• •Use of unstable doses of non-steroidal inflammatory drugs (NSAIDS) in the past 6 weeks
• •Steroid injection or intravenous (IV) infusion in the last 6 weeks
• •Use of more than 10 milligrams per day (mg/day) of oral steroids in the last 6 weeks
• •Use of biologic DMARD concurrently or recently
• •History of a serious reaction to other biological DMARDs
• •Use of an oral calcineurin inhibitor (for example, cyclosporin or tacrolimus) in the last 8 weeks
• •Surgery on a joint or other major surgery less than 2 months prior to study start, or plans to have joint surgery or major surgery during the study
• •Active fibromyalgia, juvenile chronic arthritis, spondyloarthropathy, Crohn's disease, ulcerative colitis, psoriatic arthritis, or other systemic inflammatory condition except RA
• •Cervical cancer or squamous skin cancer within the past 3 years, or other cancer within the past 5 years
• •Received a live vaccine within the past 12 weeks (for example, vaccines for measles, mumps, rubella, and chicken pox, and nasal-spray flu vaccines)
• •Hepatitis or human immunodeficiency virus (HIV)
• •A serious bacterial infection (for example, pneumonia or cellulitis) within 3 months or a serious bone or joint infection within 6 months
• •Symptoms of herpes zoster or herpes simplex within the last month
• •Active or latent tuberculosis (TB)
• •Current symptoms of a serious disorder or illness
• •Use of an investigational drug within the last month