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TERMINATEDPhase 2NCT01202110

Early Propranolol After Traumatic Brain Injury: Phase II

The primary objective of this study is to determine in patients with traumatic brain injury (TBI) the safe dosing of propranolol. Safety will be measured by episodes of bradycardia (heart rate \< 60 b...

Lead sponsor: Cedars-Sinai Medical Center•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Cedars-Sinai Medical Center

Age

18 - 100 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•patients who present within 6 hours of traumatic brain injury who have 1) a Glasgow Coma Scale (GCS) score of ≤8 or a GCS of 9-12 with computerized tomography brain scans demonstrating brain injury.

Exclusion Criteria

•pregnancy,
•patients already treated with beta-blockers,
•patients treated for antiarrhythmic, immunosuppressive or antiinfective treatment,
•myocardial infarction during the last 3 months,
•unstable or severe heart disease,
•severe chronic obstructive pulmonary disease,
•serious liver disease,
•cardiac ischemia that prevents the initiation of vasopressors,
•signs of cardiac arrhythmia or heart block on EKG,
•ischemic limb disease that prevents the initiation of vasopressors, vasopressors at maximum dose defined as norepinephrine at 40µg/min or neosynephrine at 300µg/min.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 13, 2016Terms

Trial snapshot

StatusTERMINATED

PhasePHASE2

Enrollment10

Start dateJun 2010

Last updatedMay 13, 2016

Condition

Traumatic Brain Injury

Locations shown

Cedars-Sinai Medical Center

Los Angeles, California

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 13, 2016Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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