History of type 1 diabetes mellitus, diabetic ketoacidosis, hyperosmolar nonketonic syndrome, incontinence, or nocturia

Current use of any blood glucose-lowering agent other than metformin

Exposure to insulin, thiazide, or loop diuretics within 4 weeks prior to screening

History of HIV, Hepatitis B, or Hepatitis C

Surgery within 6 months of screening

Donation or loss of \>400 mL of blood or blood product within 8 weeks prior to start of study

Use of proteins or antibodies within 12 weeks prior to screening. (Flu shots are allowed.)

Exposure to any investigational agent or participation in an investigational trial within 30 days of the start of the study

History of drug or alcohol abuse within 12 months prior to screening.

Study of Two Oral Formulations of LX4211 in Patients With Type 2 Diabetes Mellitus