Pneumothorax in the past, per anamnesis.

Women at the age of fertility, who are pregnant, or plan pregnancy, or do not use contraceptive.

Severe cardiac disease, e.g., Congestive Heart Failure (CHF) grade 3 or higher

Coronary Artery Bypass Graft (CABG) or Acute Myocardial Infarction (MI) within last 3 months

Other severe systemic disease

Non-cooperative or non-compliant patient

PulseHaler Drug Deposition Study in Chronic Obstructive Pulmonary Disease Patients