A Study to Assess the Effect of Hepatic Function on the Pharmacokinetics and Safety of ASP1941

Exclusion Criteria

• •Subjects with Moderate Hepatic Impairment
• •* Has history or presence of biliary obstruction or biliary disease, hepatic encephalopathy, advanced ascites, portal hypertension, esophageal /gastric variceal bleeding, hepatocellular carcinoma, previous liver transplantation.
• •* Has severe or moderate renal dysfunction
• •* Known to be human immunodeficiency virus (HIV) positive
• •* Has clinically significant history or presence of illness, malignancy or immunodeficiency
• •* Has had a blood transfusion or donated / lost 450 mL of blood or more within 60 days of study drug administrations or donated plasma within 7 days prior to clinical check-in
• •* Has history of alcoholism or drug/chemical/substance abuse within past 2 years
• •Subjects with Normal Hepatic Function
• •* Has severe or moderate renal dysfunction
• •* Known to be human immunodeficiency virus (HIV) positive
• •* Has clinically significant history or presence of illness, malignancy or immunodeficiency
• •* Has had a blood transfusion or donated / lost 450 mL of blood or more within 60 days of study drug administrations or donated plasma within 7 days prior to clinical check-in
• •* Has history of alcoholism or drug/chemical/substance abuse within past 2 years