Histologic documentation of diffuse large B-cell lymphoma, or any of its variants as defined in the WHO classification

Completion of at least 4 cycles of a rituximab-containing, anthracycline-based combination chemotherapy

Negative post-chemotherapy (or interim) PET scan

Absolute neutrophil count greater than 1500 and platelet count greater than 40,000

Negative pregnancy test in women of child-bearing potential

For patients with HIV/AIDS, the following must be true:

The patient is compliant on combination anti-retroviral therapy (CART)

The patient has CD4 count ≥ 200 at time of diagnosis

Reduced Radiation in Patients With Diffuse Large B-cell Lymphoma