Treatment of Forehead/Glabellar Rhytide Complex With Combination Botulinum Toxin A and Hyaluronic Acid Versus Botulinum Toxin A Injection Alone

Exclusion Criteria

• •Pregnant or lactating
• •Has received the following treatments in the forehead or glabellar region:
• •* botulinum toxin injections in the past 6 months
• •* ablative laser procedure in the past 6 months
• •* radiofrequency device treatment in the past 6 months
• •* ultrasound device treatment in the past 6 months
• •* medium to deep chemical peel in the past 6 months
• •* temporary soft tissue augmentation material in the past year
• •* semi-permanent soft tissue augmentation material in the past 2 years
• •* permanent soft tissue augmentation material
• •Is planning to receive within the next 6 months, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures) in the forehead or glabellar region.
• •Is planning to use tretinoin or retinoic acid in the next 6 months
• •Has an active infection in the forehead or glabellar region (excluding mild acne)
• •Is allergic to cow's-milk protein
• •Is allergic to albumin
• •Taking aminoglycoside
• •Has prior history of nodule formation or hypersensitivity reactions to lidocaine or hyaluronic acid derivatives
• •Is currently using anticoagulation therapy
• •Has a history of bleeding disorders
• •Is unable to understand the protocol or to give informed consent
• •Has a mental illness