Patients with metastatic colon or rectal cancer scheduled for a first-line systemic treatment;

Untreated brain metastases, spinal cord compression or primary brain tumours;

Pregnant or lactating women;

Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study start;

Treatment with any investigational drug, or participation in another investigational study, within 30 days prior to enrollment.

A Study of Avastin (Bevacizumab) Combined With Chemotherapy in Patients With Metastatic Cancer of the Colon or Rectum