Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Texas Tech University Health Sciences Center
With
National Center for Research Resources (NCRR)
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Male and female subjects, age \>18 years, of all racial and ethnic origins.
Non-English speaking Spanish speakers will be included in the study.
We are recruiting 12 normal or underweight (BMI \<25 kg/m2), 12 overweight or obese (BMI 25-40 kg/m2), and 12 extremely obese (BMI \> 40 kg/m2) for this study. This index is calculated using the volunteer's height and weight (Formula: weight (lb) / \[height (in)\]2 x 703). Half of each group will be male; the other half will be female.
You may not be if
Pregnant or nursing or unwilling to use a reliable contraception method during the study. The effects of dapsone on pregnancy are unknown. In addition, the metabolic changes that accompany pregnancy may alter the concentration-time profile of dapsone, so that the pregnancy and post-partum state would be a confounding variable.
Abnormal liver function tests: transaminases\>10 times upper limit of normal, Alkaline phosphatase\>5 times upper limit of normal, total bilirubin\>5 times upper limit of normal.
History of allergies to dapsone, sulfones, or sulfonamides.
Dapsone, sulfones, or sulfonamides are contraindicated for any reason.
Volunteers unwilling to comply with study procedures.
Current suspected or documented infection of any kind.
Volunteers with colon resection, gastric bypass, lap band, or any other conditions inhibiting gastric absorption of drug.
Current or previous participation within 28 days of enrollment in another research study that involves the use of medication, contrast, or any other compound that may alter blood count and/or blood chemistry (liver function, kidney function or electrolyte balance), unless waved by PI.
Donation of 450 milliliters (ml) (one unit) of blood or more within 8 weeks (56 days) prior to study enrollment, unless waved by PI.
Current use of zidovudine, amprenavir, rifabutin, rifapentine, or saquinavir.
Creatinine clearance \< 70 ml/minute (min) as estimated by the Cockcroft-gault equation.
Clareo Health | Effect of Weight and/or Obesity on Dapsone Drug Concentrations
