Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Eli Lilly and Company
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Nonsquamous Non-Small Cell Lung Cancer that was confirmed by tissue biopsy
Stage IIIAN2 disease (T1aN2, T1bN2, T2aN2, T2bN2, and T3N2)
Tumor considered potentially resectable
Good performance status (score of 0 or 1) according to Eastern Cooperative Oncology Group scale (ECOG)
No prior therapy for lung cancer
Measurable disease according to version 1.1 of Response Evaluation Criteria in Solid Tumors (RECIST) Criteria
Life expectancy of at least 6 months
Organs are functioning well (bone marrow reserve, liver, kidney, lung)
Signed Informed Consent
Women must be surgically sterile, postmenopausal, or compliant with a medically approved contraceptive regimen (for example, intrauterine device, birth control pills, or barrier device) during and for 6 months after last dose of study drug; must have a negative pregnancy test within 7 days before study enrollment; and must not be breast-feeding.
Men must be surgically sterile, or compliant with a contraceptive regimen during and for 6 months after last dose of study drug.
Be fit for surgery at the time of enrollment
You may not be if
Receiving or have received an investigational drug or device within the last 30 days
Have previously completed or withdrawn from this study or any other study investigating pemetrexed
Serious concomitant systemic disorder
Serious cardiac condition, such as myocardial infarction within 6 months, angina, or heart disease
Receiving concurrent administration of any other anticancer therapy
Have received a recent (within 30 days of enrollment) or are receiving concurrent yellow fever vaccination
Inability or unwillingness to take Pemetrexed supplementation/premedication (folic acid, vitamin B12, or corticosteroids)
Inability to interrupt aspirin or other nonsteroidal anti-inflammatory agents, other than an aspirin dose less than or equal to 1.3 grams per day
