Permanent Atrial fibriLLAtion Outcome Study Using Dronedarone on Top of Standard Therapy

Inclusion Criteria

• •Permanent AF defined by the presence of all of the following criteria:
• •* Availability of one 12-lead ECG not more than 14 days prior to randomization showing that the patient is in AF or atrial flutter;
• •* Availability of documentation (including either rhythm strips or medical report of the rhythm) showing that the patient was in AF or atrial flutter at least 6 months prior to randomization;
• •* No evidence of sinus rhythm in the period between these two documentations of AF;
• •* Decision of the patient and physician to allow AF to continue without further efforts to restore sinus rhythm.
• •At least one of the following risk criteria:
• •* Coronary artery disease;
• •* Prior stroke or Transient Ischemic Attack \[TIA\];
• •* Symptomatic heart failure;
• •* Left ventricular ejection fraction \[LVEF\] less or equal to 0.40;
• •* Peripheral arterial occlusive disease;
• •* Aged 75 years or older with both hypertension and diabetes mellitus.