The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease

Exclusion Criteria

• •Participants with the following history will be excluded from part 1 of the study:
• •Any glucocorticoid use within approximately 14 days of scheduled visit 1 including oral, inhaled, nasal sprays, and cream (dermal/mucosal)
• •Pregnant or currently breastfeeding
• •Planning to use certain medications because they can affect test results.
• •Any condition that, in the investigator's opinion, places the participant at undue risk for complications.
• •Participants with the following history will be excluded from part 2 of the study to avoid confounding the dexamethasone suppression test:
• •Any glucocorticoid use within approximately 14 days of scheduled visit 2 including oral, inhaled, nasal sprays, and cream (dermal/mucosal)
• •Pregnant or currently breastfeeding
• •Currently enrolled in another clinical research study and/or is receiving an investigational agent for any reason
• •Does not agree to take dexamethasone at scheduled time
• •Planning to use certain medications such as corticosteroids, estrogens, or tetracyclines prior to the visit 2, because they can affect test results. If the participant is willing to withhold these medications for 14 days, then the participant will be allowed to participate in visit 2.
• •Participants with the following history will be excluded from part 2 of the study because the dexamethasone may cause potential harm to the participant:
• •High blood pressure of 160/10 mm Hg or above.
• •Active coronary artery disease (angina) or moderate to severe heart failure stage New York Heart Association III-IV
• •Renal failure
• •Glaucoma
• •Uncontrolled psychiatric disorders such as bipolar disorder or schizoaffective disorder
• •Active systemic fungal infection
• •Prior hypersensitivity reaction to Dexamethasone
• •Currently receiving treatment for cancer (certain cancers, like lung cancer make adrenocorticotropic hormone (ACTH), and all induce stress)
• •Any condition that, in the investigator's opinion, places the participant at undue risk for complications