Lead Sponsor

Lantheus Biosciences Ltd.

Age

60 - No limit years

Sex

ALL

Healthy Volunteers

No

•Presence of MCI defined as abnormal cognition on objective testing in the absence of dementia or significant functional loss.
•Absence of systemic or other neurological disease that may contribute to cognitive impairment or prevent follow-up over two years.
•Able to give written informed consent.
•Age \>/= 60 years of age
•\>/= 7 years of education

•Mini mental state examination (MMSE) score \< 24 at baseline
•Clinical dementia rating (CDR) score \> 0.5 at baseline
•Patients who receive regular medication of drugs which may adversely impact cognition (e.g. tricyclic antidepressants, antipsychotics and/or large doses of hypnotics or anxiolytics)
•Existing or history of cancer
•History of severe head trauma, brain surgery or intracranial hematoma with permanent brain lesion
•Lifetime history of major affective disorder, schizophrenia, or schizo-affective disorder
•Contraindications to MRI (Magnetic resonance imaging)
•Relevant history, physical or imaging findings of neurological disease other than MCI and mild depression
•History of severe anaphylactic reaction or high risk of allergic reaction to drugs
•Patient has received another investigational drug in the preceding 14 days