Autonomic Nervous System and Nitric Oxide Interactions

Inclusion Criteria

• •For lean healthy volunteers:
• •20 subjects (10 males and 10 females) aged 18-60 yr.
• •All potential volunteers will have routine blood test to screen for hepatic, renal, and hematological abnormalities.
• •Body mass index \< 25Kg/m2 .
• •Female volunteers of childbearing potential will undergo HCG pregnancy test at screening and again on the study day.
• •For Obese subjects with high blood pressure.
• •20 subjects (10 males and 10 females) aged 18-60 yr.
• •All potential volunteers will have routine blood test to screen for hepatic, renal, and hematological abnormalities.
• •Body mass index \> 30 and less than 40 Kg/m2
• •\*High blood pressure (systolic=130 and diastolic = 85 mmHg)
• •Female volunteers of childbearing potential will undergo serum HCG pregnancy test at screening and urine HCG pregnancy test again on the study day.