Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray

Exclusion Criteria

• •1. definite plan to quit smoking in next 30 days
• •2. consumption of more than 15 alcoholic drinks per week during the past month
• •3. use of any illicit drugs more than twice per week during the past month
• •--Drug Use Survey (items 2-4)
• •4. pregnant or nursing
• •--Urine pregnancy test
• •5. HIV positive
• •--Oral HIV test
• •6. untreated cardiovascular or pulmonary disease
• •7. use of nicotine replacement products, bupropion or varenicline, in the past 3 months if specifically used to stop smoking
• •8. Past history of schizophrenia or bipolar disorder.
• •Current Major Depression Disorder, Diagnosis or treatment for Major Depressive Disorder in past 12 months. (H\&P)
• •Evidence of current ADHD by current diagnosis or medication or score on Adult Symptom Rating Scale; (\> 16 on pt A or B must be evaluated by a counselor)
• •* SCL-90 \> 65 (must be evaluated by a counselor)
• •* Beck Depression Inventory-II score greater than or equal to 14 (must be evaluated by a counselor)
• •9. vital signs (must be outside these parameters on more than two occasions separated by at least one day):
• •* systolic blood pressure: minimum 95, maximum 160 mm Hg
• •* diastolic blood pressure: minimum 40, maximum 95 mm Hg
• •* pulse: minimum 50, maximum 105 bpm
• •* respirations: minimum 8, maximum 24 breaths per minute
• •10. nasal passages: no pathology that would preclude administration of nasal spray
• •11. under the influence of a drug or alcohol at experimental sessions