Previous documented allergy to buprenorphine or morphine.

Are dependent on other drugs besides opioids and tobacco.

Have current history of significant use of alcohol or sedative/hypnotics.

Have evidence of significant medical (e.g., insulin dependent diabetes mellitus) or psychiatric (e.g., schizophrenia) illness.

Are pregnant (female volunteers will receive a pregnancy test before participation in the study and routinely during the study).

Have an abnormal or prolongation of the corrected QT interval (QTc) on a baseline electrocardiogram (ECG).

Are seeking treatment for their substance dependence.

A Within Subject Comparison of Opioid Withdrawal in Opioid Dependent Individuals