Double-Blind Randomized Crossover Trial to Access Electrocardiogram Effects of HPN-100

Exclusion Criteria

• •History or clinical manifestations of significant allergic, metabolic, hepatic, renal, endocrine, hematological, pulmonary, cardiovascular, gastrointestinal, urological, neurological, or psychiatric disorders
• •History of hypersensitivity or allergies to any drug compound
• •History of stomach or intestinal surgery or resection
• •History or presence of an abnormal ECG
• •History of alcoholism or drug addiction within 1 year
• •Use of any tobacco-containing or nicotine-containing products within 3 months
• •Participated in any other clinical trial of an investigational drug (or a medical device) within 30 days
• •Use of any prescription medications/products other than contraceptives within 14 days
• •Use of any over-the-counter, non-prescription preparations (including vitamins, minerals, and phytotherapeutic/herbal/plant-derived preparations) within 7 days
• •Test positive for drug(s) of abuse, ethanol, or cotinine
• •Have donated blood or blood components within 30 days
• •Have received blood products within 2 months
• •Have a history of unexplained syncope
• •Have a family history of unexplained sudden death