Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury

Exclusion Criteria

• •Suspected TBI Subjects
• •1. Considered to be psychiatrically unstable by the patient s attending physician
• •2. Contraindication to MRI scanning including: pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pump, or shrapnel fragments.
• •3. Conditions precluding entry into the scanner such as morbid obesity or claustrophobia or conditions requiring sedation.
• •4. In female subjects, pregnancy.
• •Healthy Volunteers
• •1. Presence of cognitive impairment based on medical history and/or Mini Mental State Examination (MMSE) score of \< 27
• •2. Current or past DSM-IV diagnosis of a psychiatric disorder including substance use disorder as determined by self-report, medical history, and/or clinical exam
• •3. Major medical problems that can impact brain function (e.g., problems of the CNS including seizures and psychosis; cardiovascular disease including hypertension and arrhythmias; metabolic, autoimmune, endocrine disorders) as determined by self-report, medical history and/or clinical exam;
• •4. Contraindication to MRI scanning including certain metal implants or devices such as: cardiac pacemaker, insulin infusion pump, implanted drug infusion device, cochlear, otologic, or ear implant, transdermal medication patch (Nitroglycerine) that cannot be removed for the study, body piercing(s), bone/joint pin, screw, nail, plate, wire sutures or surgical staples, shunts, cerebral aneurysms clips, shrapnel or other metal imbedded in a subject s body (such as from war wounds or accidents or previous work in metal fields or machines that may have left any metallic fragments in or near the subject s eyes).
• •5. Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophobia, etc.).
• •6. In female subjects, pregnancy or breastfeeding.
• •7. Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits.
• •Currently Phase-1 of enrollment for healthy volunteers in the A Beta PET pilot is complete. At this time enrollment of healthy volunteers is on hold until analysis complete. Enrollment of A Beta PET pilot TBI subjects and healthy matches may resume under Phase-2 if analysis of initial data suggests update