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Acetazolamide Facilitates Ventilator Weaning | Clinical Trials | Clareo Health

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Acetazolamide Facilitates Ventilator Weaning

Acetazolamide Facilitates Ventilator Weaning Multicenter, Prospective, Double Blinded, Randomised Controlled Trial

NCT01131377•Asan Medical Center

Summary

Metabolic alkalosis(MA) is common metabolic disorder in ICU setting. MA could be cause of weaning failure or delay by depression of respiratory center. The purpose of this study is to evaluate that correction of MA by administration of acetazolamide facilitates weaning of mechanical ventilation.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients on mechanical ventilation for at least 24 hours with an assisted mode and passed acute resuscitation and considered for weaning. (Definition of Weaning point:
•1. Oxygenation
•* FiO2 ≤ 0.4 \& PaO2 ≥ 60 mmHg
•* O2 index (PaO2/FiO2) ≥ 150
•* SaO2 \> 90%
•* PEEP ≤ 5 cmH2O
•* MN ≤ 15 L/min
•2. Vital sign
•* Stable BP: MAP ≥ 60 mmHg ((i.e., no epinephrine or norepinephrine \<0.2μg/kg/min, or equivalent dose vasopressin or phenylephrine)
•* HR ≤ 140bpm
+10 more criteria

Exclusion Criteria

•Permanent ventilator dependency due to brainstem disease, diffuse cerebral disease, severe respiratory or neuromuscular disease
•Active bleeding, IICP, unstable coronary artery disease, bronchospasm, and rescue treatment (inhaled NO, prone), pre-op condition
•Contraindication to acetazolamide: renal insufficiency (creatinine clearance \<20 ml/min and/or renal replacement therapy), intolerance or allergy to acetazolamide or sulfonamides, hyperchloremic metabolic acidosis, hyponatremia (Na\<130), hypokalemia (K\<3.5), adrenal insufficiency.
•Diaphragm dysfunction : as diagnosed by fluoroscopy, nerve conduction velocity, USG, or overt paradoxical motion of the abdomen

Locations (1)

AMC MICU; Asan medical center

Seoul, 388-1, Pungnap-dong, Songpa-gu, South Korea

Key Dates

Start Date

May 1, 2010

Primary Completion Date

May 1, 2011

Completion Date

May 1, 2011

Last Updated

May 27, 2010

Enrollment

150

ESTIMATED participants

Conditions

Ventilator WeaningAlkalosis, Metabolic

Interventions

acetazolamide

DRUG

Saline

DRUG

Contacts

Eun Young Choi, Fellow

CONTACT

+82-2-3010-3894 letact@hanmail.net

Chae-Man Lim, professor

CONTACT

+82-2-3010-3135 cmlim@amc.seoul.kr

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 27, 2010Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Acetazolamide Facilitates Ventilator Weaning

Inclusion Criteria

Exclusion Criteria

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