Asymptomatic Brain Metastasis in Non-small Cell Lung Cancer (NSCLC)

Inclusion Criteria

• •Histologically confirmed non-small cell lung cancer with synchronous brain metastases (diagnosis of brain lesion before or within 2 months from diagnosis of the primary site tumor)
• •* One to 4 intraparenchymal brain metastases by contrast-enhanced MRI, meeting the following criteria:
• •1. Well circumscribed tumor(s) with brain edema Grade 0-1
• •2. Maximum diameter ≤ 3.0 cm
• •* No prior complete resection of all known brain metastases or RT ④ No leptomeningeal metastases by MRI or cerebrospinal fluid evaluation
• •* Patients without any symptoms or signs from brain metastases (RTOG neurologic functions status of 0) ⑥ Age, 18 and over ⑦ ECOG performance status 0-1 ⑧ Written informed consent