We hypothesize that Secretol 80/80 daily will demonstrate better efficacy than Nexium 40 mg daily in healing erosive esophagitis(EE)and controlling gastroesophageal reflux disease(GERD)related symptoms after 3 weeks of treatment.In addition, Secretol 80/80 daily will have a faster effect on the aforementioned clinical parameters but a similar safety profile.
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male or Female
Ages 18-75
EE Los Angeles grades C or D
Heartburn and/or regurgitation at least 3 times a week during the 7 day run- in period prior to randomization.
Able to read, understand, and complete study questionnaires and record
Able to understand the study procedures and sign informed consent
Able to comply with all study requirements
You may not be if
Subjects with Barrett's esophagus, non-erosive reflux disease,EE grades A or B, or peptic stricture on endoscopy
Subjects with previous upper gastrointestinal surgery
Subjects with clinically significant underlying comorbidity
Helicobacter pylori positive
Clinically significant GI bleed within the last 3 months
